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In an ischemic stroke model, exendin-4 enhanced the activation of PI3K/Akt/CREB signaling, leading to upregulation of APE1, a key enzyme responsible for resolving oxidized bases and single-strand breaks, which reduced nuclear DNA fragmentation and preserved neuronal viability (75, 76)

And for many users, the fatigue is significant enough to affect daily functioning, work performance, and exercise capacity

second, they act in the human brain to suppress hunger and create feelings of fullness

Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions